Publications

Selected Publication


  1. Takahashi N (Shared Corresponding Author), Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP, and Brugge JS (Shared Corresponding Author). "3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis".

Molecular Cell 80, 828–844 (2020).


  1. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, and Brugge JS. "Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative Stress Tolerance".

Cancer Cell 33, 985–1003 (2018).


  1. Takahashi N, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y, Kitamata M, Matsuoka R, Hanawa-Suetsugu K, Senju Y, Mori MX, Kiyonaka S, Kohda D, Kitao A, Mori Y, and Suetsugu S. "TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2."

Nature Commun. 5, 4994 (2014).


  1. Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, and Mori Y. "TRPA1 underlies a sensing mechanism for O2"

Nature Chem. Biol. 7, 701–711 (2011).


Introduced in Nature as a "Nobel Prize in Physiology or Medicine 2019"-related study .


All Publications


  1. Akito Nakao, Yoshihiro Matsunaga, Katsumi Hayashida and Nobuaki Takahashi*. "Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders".

Front. Cell Dev. Biol. in press.

  1. Nobuaki Takahashi (Shared Corresponding Author), Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP, and Brugge JS (Shared Corresponding Author). "3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis".

Molecular Cell 80, 828–844 (2020).

Previews by Wu WL and Papagiannakopoulos T

  1. Chen S, Nobuaki Takahashi (Co-First Author), Chen S, Pauli JL, Kuroki CM, Kaminosono J, Kashiwadani H, Kanmura Y, Mori Y, Ou S, Hao L, and Kuwaki T. "TRPA1 mediates hypoxic responses in mice".

Front. in Physiology 11, 576209 (2020).


  1. Uchiyama M, Nakao A, Kurita Y, Fukushi I, Takeda K, Numata T, Tran HN, Sawamura S, Ebert M, Kurokawa T, Sakaguchi R, Stokes AJ, Nobuaki Takahashi, Okada Y, Mori Y. "O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses".

Current Biology 30, 3378–3396 (2020).


  1. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Nobuaki Takahashi, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS."Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion".

Cell Metabolism 29, 1166–1181 (2019).


  1. Nobuaki Takahashi, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, and Brugge JS. "Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative Stress Tolerance".

Cancer Cell 33, 985–1003 (2018).

Selected as the Featured Article of the issue in Cancer Cell. Previews by Reczek CR and Chandel NS.Highlighted in Cancer Discovery. Recommended by f1000prime (f1000.com/733287566).

  1. Miyake T, Nakamura S, Meng Z, Hamano S, Inoue K, Numata T, Nobuaki Takahashi, Nagayasu K, Shirakawa H, Mori Y, Nakagawa T, and Kaneko S. "Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin".

Front. Physiol. 8, 878 (2017).


  1. Mori Y, Nobuaki Takahashi, Kurokawa T, and Kiyonaka S. "TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing".

Proc. Jpn. Acad. Ser B Phys. Biol. Sci. 93, 464–482 (2017).


  1. Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, Nobuaki Takahashi, Shirakawa H, Mori Y, Nakagawa T, and Kaneko S. "Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS".

Nature Commun. 7, 12840 (2016).


  1. Shibata T, Takahashi K, Matsubara Y, Inuzuka E, Nakashima F, Nobuaki Takahashi, Kozai D, Mori Y, and Uchida K. "Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel".

Sci. Rep. 6, 21261 (2016).


  1. Ogawa N, Kurokawa T, Fujiwara K, Polat OK, Badr H, Nobuaki Takahashi, and Mori Y. "Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification".

J. Biol. Chem. 291, 4197–4210 (2016).


  1. Mori Y, Nobuaki Takahashi, Ogawa N, and Gudermann T. "Oxygen physiology: sensors and ion channels".

Pflugers Arch. 468, 1–2 (2016).


  1. Mori Y, Nobuaki Takahashi, Polat OK, Kurokawa T, Takeda N, and Inoue M. "Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation".

Pflugers Arch. 468, 85–97 (2016).


  1. Nobuaki Takahashi, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y, Kitamata M, Matsuoka R, Hanawa-Suetsugu K, Senju Y, Mori MX, Kiyonaka S, Kohda D, Kitao A, Mori Y, and Suetsugu S. "TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2".

Nature Commun. 5, 4994 (2014).


  1. Shimizu S, Yonezawa R, Hagiwara T, Yoshida T, Nobuaki Takahashi, Hamano S, Negoro T, Toda T, Wakamori M, Mori Y, and Ishii M. "Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry".

Eur J Pharmacol. 742C, 22–30 (2014).


  1. Kozai D, Kabasawa Y, Ebert M, Kiyonaka S; Firman, Otani Y, Numata T, Nobuaki Takahashi, Mori Y, and Ohwada T. "Transnitrosylation directs TRPA1 selectivity in N-nitrosamine activators".

Mol. Pharmacol. 85, 175–185 (2014).


  1. Shimizu S, Nobuaki Takahashi, and Mori Y. "TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters)".

Handb. Exp. Pharmacol. 223, 767–794 (2014).


  1. Nobuaki Takahashi and Mori Y. "The O2-sensing TRPA1 channel illustrates the significance of vagal nerves in cardio-respiratory adaptation to hypoxia".

Acta Physiol. (Oxf) 210, 705–707 (2014).


  1. Yonemitsu T, Kuroki C, Nobuaki Takahashi, Mori Y, Kanmura Y, Kashiwadani H, Ootsuka Y, and Kuwaki T. "TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep".

Sci. Rep. 3, 3100 (2013).


  1. Numata T, Ogawa N, Nobuaki Takahashi, and Mori Y. "TRP channels as sensors of oxygen availability".

Pflugers Arch. 465, 1075–1085 (2013).


  1. Nobuaki Takahashi, Kozai D, and Mori Y. "TRP channels: sensors and transducers of gasotransmitter signals".

Front. Physiol. 3, 324 (2012).


  1. Nobuaki Takahashi, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, and Mori Y. "TRPA1 underlies a sensing mechanism for O2".

Nature Chem. Biol. 7, 701–711 (2011).

Introduced in Nature as a "Nobel Prize in Physiology or Medicine 2019"-related study . News and views by Zygmunt PM.Recommended by f1000prime (f1000.com/13923984).

  1. Nobuaki Takahashi and Mori Y. "TRP Channels as Sensors and Signal Integrators of Redox Status Changes".

Front. Pharmacol. 2, 58 (2011).

Selected as the highest-performing articles in Frontiers (1,764 total views in 2012).

  1. Nobuaki Takahashi, Kozai D, Kobayashi R, Ebert M, and Mori Y. "Roles of TRPM2 in oxidative stress".

Cell Calcium 50, 279–287 (2011).


  1. Numata T, Kiyonaka S, Kato K, Nobuaki Takahashi, and Mori Y. "Activation of TRP channels in mammalian systems".

TRP CHANNELS (Methods in signal transduction series) 43–90 (2011).


  1. Mori Y, Kajimoto T, Nakao A, Nobuaki Takahashi, and Kiyonaka S. "Receptor signaling integration by TRP channelsomes".


Adv. Exp. Med. Biol. 704, 373–389 (2011).


  1. Bogeski I, Kummerow C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Nobuaki Takahashi, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, and Niemeyer BA. "Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling".

Science Signal. 3, ra24 (2010).

Recommended by f1000prime (f1000.com/ 4159956).

  1. Yamamoto S, Nobuaki Takahashi, and Mori Y. "Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels".

Prog. Biophys. Mol. Biol. 103, 18–27 (2010).


  1. Nobuaki Takahashi, Mizuno Y, Kozai D, Yamamoto S, Kiyonaka S, Shibata T, Uchida K, and Mori Y. "Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators".

Channels 2, 287–298 (2008).

The most cited Research Article in that journal's 13-year history.

  1. Yamamoto S, Shimizu S, Kiyonaka S, Nobuaki Takahashi, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, and Mori Y. "TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration".

Nature Med. 14, 738–747 (2008).

Recommended by f1000prime (f1000.com/ 1116116)

  1. Yoshida T, Inoue R, Morii T, Nobuaki Takahashi, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, and Mori Y. "Nitric oxide activates TRP channels by cysteine S-nitrosylation".

Nature Chem. Biol. 2, 596–607 (2006).

News and views by Foster MX, Hess DT, and Stamler JS.