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Welcome to Nobuaki Takahashi Research Group
Welcome to Nobuaki Takahashi Research Group
Nobuaki Takahashi Research Group focuses on understanding how the body senses and responds to cellular stresses, including oxidative, hypoxic, and acidic stress. Specifically, we investigate molecular mechanisms of stress sensing and adaptation in cancer cells, neurons, and other types of cells.
Nobuaki Takahashi Research Group focuses on understanding how the body senses and responds to cellular stresses, including oxidative, hypoxic, and acidic stress. Specifically, we investigate molecular mechanisms of stress sensing and adaptation in cancer cells, neurons, and other types of cells.
In the projects regarding cancer, we utilize three-dimensional (3D) spheroid models, which recapitulate in vivo morphologies such as cell polarization, organization of cell layers, and interactions with ECM, as well as mouse models and patient samples, in order to identify molecular mechanisms by which cancer cells are to survive under harsh stress conditions.
In the projects regarding cancer, we utilize three-dimensional (3D) spheroid models, which recapitulate in vivo morphologies such as cell polarization, organization of cell layers, and interactions with ECM, as well as mouse models and patient samples, in order to identify molecular mechanisms by which cancer cells are to survive under harsh stress conditions.
In the projects regarding neurons and other types of cells, we mainly focus on Ca2+-permeable TRP channels, which play important roles in sensing of numerous stress stimuli, to uncover the significance of stress sensing in life phenomena, including physiology and pathology, and evolution of life.
In the projects regarding neurons and other types of cells, we mainly focus on Ca2+-permeable TRP channels, which play important roles in sensing of numerous stress stimuli, to uncover the significance of stress sensing in life phenomena, including physiology and pathology, and evolution of life.
The mechanisms underlying stress sensing are exclusively based on chemical reactions. I believe that my background in chemical biology, neuroscience, and cancer biology uniquely enables me to view biology and medicine from a different perspective and bring a new area of expertise to the fields.
The mechanisms underlying stress sensing are exclusively based on chemical reactions. I believe that my background in chemical biology, neuroscience, and cancer biology uniquely enables me to view biology and medicine from a different perspective and bring a new area of expertise to the fields.
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