Molecular Mechanisms of Stress Sensing and Adaptation in Life
Welcome to Nobuaki Takahashi Research Group
Welcome to Nobuaki Takahashi Research Group
Nobuaki Takahashi Research Group focuses on understanding how the body senses and responds to cellular stresses, including oxidative, hypoxic, and acidic stress. Specifically, we investigate molecular mechanisms of stress sensing and adaptation in cancer cells, neurons, and other types of cells.
Nobuaki Takahashi Research Group focuses on understanding how the body senses and responds to cellular stresses, including oxidative, hypoxic, and acidic stress. Specifically, we investigate molecular mechanisms of stress sensing and adaptation in cancer cells, neurons, and other types of cells.
In the projects regarding cancer, we utilize three-dimensional (3D) spheroid models, which recapitulate in vivo morphologies such as cell polarization, organization of cell layers, and interactions with ECM, as well as mouse models and patient samples, in order to identify molecular mechanisms by which cancer cells are to survive under harsh stress conditions.
In the projects regarding cancer, we utilize three-dimensional (3D) spheroid models, which recapitulate in vivo morphologies such as cell polarization, organization of cell layers, and interactions with ECM, as well as mouse models and patient samples, in order to identify molecular mechanisms by which cancer cells are to survive under harsh stress conditions.
In the projects regarding neurons and other types of cells, we mainly focus on Ca2+-permeable TRP channels, which play important roles in sensing of numerous stress stimuli, to uncover the significance of stress sensing in life phenomena, including physiology and pathology, and evolution of life.
In the projects regarding neurons and other types of cells, we mainly focus on Ca2+-permeable TRP channels, which play important roles in sensing of numerous stress stimuli, to uncover the significance of stress sensing in life phenomena, including physiology and pathology, and evolution of life.
The mechanisms underlying stress sensing are exclusively based on chemical reactions. I believe that my background in chemical biology, neuroscience, and cancer biology uniquely enables me to view biology and medicine from a different perspective and bring a new area of expertise to the fields.
The mechanisms underlying stress sensing are exclusively based on chemical reactions. I believe that my background in chemical biology, neuroscience, and cancer biology uniquely enables me to view biology and medicine from a different perspective and bring a new area of expertise to the fields.
NEWS
NEWS
March 2022:
March 2022:
Nobu gave a talk at the clinical-engineering networking event (iACT) at Kyoto University.
Nobu gave a talk at the clinical-engineering networking event (iACT) at Kyoto University.
March 2022:
March 2022:
Nobu gave a talk at IRCMS at Kumamoto University.
Nobu gave a talk at IRCMS at Kumamoto University.
October 2021:
October 2021:
Nobu got the Astellas award for the outstanding presentation selected by the peer review.
Nobu got the Astellas award for the outstanding presentation selected by the peer review.
February 2021:
February 2021:
Nobu gave a talk at the Smart Aging Research Center at Tohoku University.
Nobu gave a talk at the Smart Aging Research Center at Tohoku University.
February 2021:
February 2021:
Our review paper entitled "Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders" has been published in Front. Cell Dev. Biol.
Our review paper entitled "Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders" has been published in Front. Cell Dev. Biol.
December 2020:
December 2020:
Nobu gave a talk at Cancer Program Meeting in Broad Institute of MIT.
Nobu gave a talk at Cancer Program Meeting in Broad Institute of MIT.
October 2020:
October 2020:
Our paper on the critical role of NRF2 hyperactivation on cancer spheroid formation (title: 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis) has been published in Molecular Cell.
Our paper on the critical role of NRF2 hyperactivation on cancer spheroid formation (title: 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis) has been published in Molecular Cell.
October 2020:
October 2020:
Nobu launched the Transformative Research Areas B (Acceptance Rate: 3.0%, MEXT, KAKENHI) as Head Investigator. (Homepage: https://www.transformative-research-area.ph-biology.net/)
Nobu launched the Transformative Research Areas B (Acceptance Rate: 3.0%, MEXT, KAKENHI) as Head Investigator. (Homepage: https://www.transformative-research-area.ph-biology.net/)
April 2020:
April 2020:
Nobu got the Young Scientist’s Prize for the Commendation of Science and Technology by Mr. Koichi Hagiuda, the Minister of Education, Culture, Sports, Science, and Technology (MEXT), which is an executive branch of the Government of Japan.
Nobu got the Young Scientist’s Prize for the Commendation of Science and Technology by Mr. Koichi Hagiuda, the Minister of Education, Culture, Sports, Science, and Technology (MEXT), which is an executive branch of the Government of Japan.
October 2019:
October 2019:
Our paper (Nobuaki Takahashi et al., Nature Chem. Biol. 2011) has been introduced in Nature as a "Nobel Prize in Physiology or Medicine 2019"-related study (https://www.nature.com/collections/ahehidccae).
Our paper (Nobuaki Takahashi et al., Nature Chem. Biol. 2011) has been introduced in Nature as a "Nobel Prize in Physiology or Medicine 2019"-related study (https://www.nature.com/collections/ahehidccae).
October 2019:
October 2019:
Nobu got a 3.5-year grant from Japan Agency for Medical Research and Development (AMED) ; Acceptance Rate: 7.4%.
Nobu got a 3.5-year grant from Japan Agency for Medical Research and Development (AMED) ; Acceptance Rate: 7.4%.
April 2019:
April 2019:
Nobu is selected as a member of the Hakubi project in Kyoto University. The purpose of this project is to support young scientists who are extremely talented (top 2–3%) and will pioneer new field of research.
Nobu is selected as a member of the Hakubi project in Kyoto University. The purpose of this project is to support young scientists who are extremely talented (top 2–3%) and will pioneer new field of research.